Re: [PyrNet-L] Ivermectin

["Doug Hustins" <profitmanage@mgenerations.net>]

We have dealt with a number of reproductive specialists, both ICG and other
and each and every one has told us not to use ANY dewormer on a pregnant or
lactating bitch as there was a small possibility of side effects with the
puppies including losing the litter.  I have no idea if this information is
correct or not, but as long as there is any doubt whatsoever, I will
continue to cease using any dewormer 30 days prior to breeding.

Don't stop speaking.  The exchange of ideas is what makes life interesting.

Take Care,
Doug Hustins
Acroyar Great Pyrenees.

----- Original Message -----
From: Richard Bergen <bergens@cts.com>
To: Pyr list <pyrnet-l@gamerz.net>
Sent: October 30, 1999 1:05 PM
Subject: [PyrNet-L] Ivermectin


> Patric,
> Lest I get my husband in trouble, it was I who sent this thread.  This was
> told to me by a specialist who has bred thousands of dogs and it is based
on
> observations, not medical research.  Anyway, any side effects are
temporary.
>
> This will teach me to lurk and not speak.
>
> Joanne
> Date: Fri, 29 Oct 1999 18:08:17 -0700 (PDT)
> From: pyrsrgr8@yahoo.com
> Subject: Re: [PyrNet-L] Ivermectin
>
> Richard,
>
> --- Richard Bergen <bergens@cts.com> wrote:
> > FYI, you may want to be aware that ivermectin can cause sterility in
> > dogs.
>
> Where did you get this information?  Ivermectin can cause no such
> thing!  I don't know what vet told you this or where you read it, but
> cannot be true.
>
> Here is why:
>
> Ivermectin is a GABA receptor agonist, and because mammals have GABA
> receptors only in the central nervous system, ivermectin is safe for
> all mammals unless it crosses the blood-brain barrier (as it apparently
> does in many collies and related herding-breed dogs).
>
> Side effects would be *neurological* and not reproductive, and in cases
> of an overdose, dissipates with the termination of treatment.
>
> Even collies tend to tolerate the 6 microgram/Kg body weight dose
> recommended for heartworm prevention, but should never be given higher
> doses.
>
> Ivermectin is a very widely used broad spectrum antiparasitic and if it
> caused any level of sterility half of the dogs in this country would be
> sterile (including all of ours).
>
> Sincerely, Patric.
>
>
> =====
> ______________________________________
> Patric Lundberg, PhD
> plundber@coh.org
> Department of Virology
> City of Hope National Medical Center
> (626)359-8111 x2612
> __________________________________________________
>
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