Re: [PyrNet-L] Ivermectin

[Pyrs RGreat <pyrsrgr8@yahoo.com>]

Richard,

--- Richard Bergen <bergens@cts.com> wrote:
> FYI, you may want to be aware that ivermectin can cause sterility in
> dogs.

Where did you get this information?  Ivermectin can cause no such
thing!  I don't know what vet told you this or where you read it, but
cannot be true.

Here is why:

Ivermectin is a GABA receptor agonist, and because mammals have GABA
receptors only in the central nervous system, ivermectin is safe for
all mammals unless it crosses the blood-brain barrier (as it apparently
does in many collies and related herding-breed dogs).

Side effects would be *neurological* and not reproductive, and in cases
of an overdose, dissipates with the termination of treatment.

Even collies tend to tolerate the 6 microgram/Kg body weight dose
recommended for heartworm prevention, but should never be given higher
doses.

Ivermectin is a very widely used broad spectrum antiparasitic and if it
caused any level of sterility half of the dogs in this country would be
sterile (including all of ours).

Sincerely, Patric.


=====
______________________________________
Patric Lundberg, PhD
plundber@coh.org
Department of Virology
City of Hope National Medical Center
(626)359-8111 x2612
__________________________________________________
Do You Yahoo!?
Bid and sell for free at http://auctions.yahoo.com